L59S (p.Leu59Ser) variant of IRAK4 (Q9NWZ3)
L59S (p.Leu59Ser) in IRAK4 (Q9NWZ3) is a missense change. The available variant effect predictions contribute to a CATVariant prioritization score of 0.60 / 1. The record also includes population frequency data, published literature, and structural context.
L59S (p.Leu59Ser) variant details
- p.Leu59Ser
- gnomAD 12-43771234-T-C
- Missense
- Variant Prioritization Score for Impact Estimate 0.597
- CADD 23.90
- PolyPhen-2 0.05
- SIFT 0.05
- Population evidence available
- Structural context available
- Literature evidence available