L14F (p.Leu14Phe) variant of IRAK4 (Q9NWZ3)
L14F (p.Leu14Phe) in IRAK4 (Q9NWZ3) is a missense change. The available variant effect predictions contribute to a CATVariant prioritization score of 0.67 / 1. The record also includes population frequency data and structural context.
L14F (p.Leu14Phe) variant details
- p.Leu14Phe
- ExAC rs748441973
- gnomAD rs748441973
- Missense
- Variant Prioritization Score for Impact Estimate 0.669
- CADD 24.40
- PolyPhen-2 0.99
- SIFT 0.00
- Most common in the Non-Finnish European population (allele frequency 9e-07)
- Structural context available