K64E (p.Lys64Glu) variant of IRAK4 (Q9NWZ3)
K64E (p.Lys64Glu) in IRAK4 (Q9NWZ3) is a missense change. The available variant effect predictions contribute to a CATVariant prioritization score of 0.51 / 1. The record also includes population frequency data and structural context.
K64E (p.Lys64Glu) variant details
- p.Lys64Glu
- TOPMed rs1239693276
- gnomAD rs1239693276
- Missense
- Variant Prioritization Score for Impact Estimate 0.508
- CADD 23.90
- PolyPhen-2 0.15
- SIFT 0.04
- Most common in the Non-Finnish European population (allele frequency 5.9e-05)
- Structural context available