G75S (p.Gly75Ser) variant of IRAK4 (Q9NWZ3)
G75S (p.Gly75Ser) in IRAK4 (Q9NWZ3) is a missense change. The available variant effect predictions contribute to a CATVariant prioritization score of 0.79 / 1. The record also includes population frequency data and structural context.
G75S (p.Gly75Ser) variant details
- p.Gly75Ser
- ExAC rs778743146
- gnomAD rs778743146
- Missense
- Variant Prioritization Score for Impact Estimate 0.791
- CADD 27.30
- PolyPhen-2 0.96
- SIFT 0.00
- Most common in the REMAINING population (allele frequency 1.7e-05)
- Structural context available