D73H (p.Asp73His) variant of IRAK4 (Q9NWZ3)
D73H (p.Asp73His) in IRAK4 (Q9NWZ3) is a missense change. Clinical records from UniProt describe it as variant assessed as somatic; moderate impact. The available variant effect predictions contribute to a CATVariant prioritization score of 0.61 / 1. The record also includes population frequency data and structural context.
D73H (p.Asp73His) variant details
- p.Asp73His
- NCI-TCGA TCGA novel
- Variant assessed as somatic; moderate impact.
- Missense
- Variant Prioritization Score for Impact Estimate 0.61
- AlphaMissense 0.13
- MetaLR 0.13
- MetaSVM -0.98
- CADD 27.50
- PolyPhen-2 0.97
- SIFT 0.10
- UniProt: Variant assessed as somatic; moderate impact.
- Most common in the East Asian population (allele frequency 2.5e-05)
- Structural context available