T141P (p.Thr141Pro) variant of IRAK1 (P51617)
T141P (p.Thr141Pro) in IRAK1 (P51617) is a missense change. Clinical records from ClinVar, EBI, and UniProt describe it as uncertain significance in the context of not specified. The available variant effect predictions contribute to a CATVariant prioritization score of 0.34 / 1. The record also includes population frequency data and structural context.
T141P (p.Thr141Pro) variant details
- p.Thr141Pro
- rs994323796
- ClinGen CA337256690
- ClinVar RCV004258670
- gnomAD rs994323796
- Uncertain significance
- not specified
- Missense
- Variant Prioritization Score for Impact Estimate 0.345
- REVEL 0.19
- CADD 24.50
- PolyPhen-2 1.00
- SIFT 0.15
- ClinVar: Uncertain significance (not specified)
- EBI: Variant of uncertain significance
- UniProt: Uncertain significance
- Most common in the Latino/Admixed American population (allele frequency 2.8e-05)
- Structural context available