S177F (p.Ser177Phe) variant of IRAK1 (P51617)
S177F (p.Ser177Phe) in IRAK1 (P51617) is a missense change. Clinical records from ClinVar, EBI, and UniProt describe it as conflicting interpretations in the context of not provided; not specified. The available variant effect predictions contribute to a CATVariant prioritization score of 0.24 / 1. The record also includes population frequency data and structural context.
S177F (p.Ser177Phe) variant details
- p.Ser177Phe
- rs202066173
- ClinGen CA10558325
- ClinVar RCV003440028
- ClinVar RCV005854500
- Conflicting interpretations
- not provided; not specified
- Missense
- Variant Prioritization Score for Impact Estimate 0.243
- REVEL 0.09
- CADD 22.80
- PolyPhen-2 0.31
- SIFT 0.01
- ClinVar: Conflicting classifications of pathogenicity (not provided; not specified)
- EBI: Likely benign
- UniProt: Likely benign
- Most common in the 1KG:CLM population (allele frequency 0.034)
- Structural context available