P176L (p.Pro176Leu) variant of IRAK1 (P51617)
P176L (p.Pro176Leu) in IRAK1 (P51617) is a missense change. The available variant effect predictions contribute to a CATVariant prioritization score of 0.18 / 1. The record also includes population frequency data and structural context.
P176L (p.Pro176Leu) variant details
- p.Pro176Leu
- TOPMed rs1460615442
- Missense
- Variant Prioritization Score for Impact Estimate 0.176
- REVEL 0.11
- CADD 17.90
- PolyPhen-2 0.43
- SIFT 0.13
- Most common in the Non-Finnish European population (allele frequency 1.9e-05)
- Structural context available