P145S (p.Pro145Ser) variant of IRAK1 (P51617)
P145S (p.Pro145Ser) in IRAK1 (P51617) is a missense change. The available variant effect predictions contribute to a CATVariant prioritization score of 0.31 / 1. The record also includes population frequency data and structural context.
P145S (p.Pro145Ser) variant details
- p.Pro145Ser
- TOPMed rs2065763140
- Missense
- Variant Prioritization Score for Impact Estimate 0.307
- REVEL 0.19
- CADD 23.70
- PolyPhen-2 0.53
- SIFT 0.11
- Most common in the Non-Finnish European population (allele frequency 1.2e-06)
- Structural context available