K180R (p.Lys180Arg) variant of IRAK1 (P51617)
K180R (p.Lys180Arg) in IRAK1 (P51617) is a missense change. The available variant effect predictions contribute to a CATVariant prioritization score of 0.20 / 1. The record also includes population frequency data and structural context.
K180R (p.Lys180Arg) variant details
- p.Lys180Arg
- gnomAD rs1557130517
- Missense
- Variant Prioritization Score for Impact Estimate 0.2
- REVEL 0.07
- CADD 22.80
- PolyPhen-2 0.12
- SIFT 0.08
- Most common in the South Asian population (allele frequency 0.00073)
- Structural context available