I74V (p.Ile74Val) variant of IRAK1 (P51617)
I74V (p.Ile74Val) in IRAK1 (P51617) is a missense change. The available variant effect predictions contribute to a CATVariant prioritization score of 0.27 / 1. The record also includes population frequency data and structural context.
I74V (p.Ile74Val) variant details
- p.Ile74Val
- cosmic curated COSV57656
- TOPMed rs1257648342
- gnomAD rs1257648342
- Missense
- Variant Prioritization Score for Impact Estimate 0.267
- REVEL 0.09
- CADD 21.10
- PolyPhen-2 0.19
- SIFT 0.73
- Most common in the Non-Finnish European population (allele frequency 1.9e-05)
- Structural context available