I121L (p.Ile121Leu) variant of IRAK1 (P51617)
I121L (p.Ile121Leu) in IRAK1 (P51617) is a missense change. Clinical records from ClinVar, EBI, and UniProt describe it as benign in the context of not provided. The available variant effect predictions contribute to a CATVariant prioritization score of 0.10 / 1. The record also includes population frequency data and structural context.
I121L (p.Ile121Leu) variant details
- p.Ile121Leu
- rs201911518
- ClinGen CA10558355
- cosmic curated COSV57656
- ClinVar RCV000968501
- Benign
- not provided
- Missense
- Variant Prioritization Score for Impact Estimate 0.0951
- REVEL 0.07
- CADD 9.40
- PolyPhen-2 0.00
- SIFT 0.41
- ClinVar: Benign (not provided)
- EBI: Benign
- UniProt: Benign
- Most common in the 1KG:PUR population (allele frequency 0.0069)
- Structural context available