G8E (p.Gly8Glu) variant of IRAK1 (P51617)
G8E (p.Gly8Glu) in IRAK1 (P51617) is a missense change. The available variant effect predictions contribute to a CATVariant prioritization score of 0.30 / 1. The record also includes population frequency data and structural context.
G8E (p.Gly8Glu) variant details
- p.Gly8Glu
- TOPMed rs2065769991
- Missense
- Variant Prioritization Score for Impact Estimate 0.299
- REVEL 0.16
- CADD 23.80
- PolyPhen-2 0.95
- SIFT 0.03
- Most common in the African/African-American population (allele frequency 6.2e-05)
- Structural context available