G14C (p.Gly14Cys) variant of IRAK1 (P51617)
G14C (p.Gly14Cys) in IRAK1 (P51617) is a missense change. Clinical records from UniProt describe it as variant assessed as somatic; moderate impact. The available variant effect predictions contribute to a CATVariant prioritization score of 0.29 / 1. The record also includes population frequency data and structural context.
G14C (p.Gly14Cys) variant details
- p.Gly14Cys
- NCI-TCGA Cosmic COSV1003
- cosmic curated COSV10031
- Variant assessed as somatic; moderate impact.
- Missense
- Variant Prioritization Score for Impact Estimate 0.288
- REVEL 0.19
- CADD 26.20
- PolyPhen-2 0.94
- SIFT 0.00
- UniProt: Variant assessed as somatic; moderate impact.
- Population evidence available
- Structural context available