E128K (p.Glu128Lys) variant of IRAK1 (P51617)
E128K (p.Glu128Lys) in IRAK1 (P51617) is a missense change. Clinical records from UniProt describe it as variant assessed as somatic; moderate impact. The available variant effect predictions contribute to a CATVariant prioritization score of 0.11 / 1. The record also includes population frequency data and structural context.
E128K (p.Glu128Lys) variant details
- p.Glu128Lys
- NCI-TCGA TCGA novel
- Variant assessed as somatic; moderate impact.
- Missense
- Variant Prioritization Score for Impact Estimate 0.11
- REVEL 0.02
- CADD 4.49
- PolyPhen-2 0.00
- SIFT 0.74
- UniProt: Variant assessed as somatic; moderate impact.
- Most common in the South Asian population (allele frequency 1.9e-05)
- Structural context available