P357L (p.Pro357Leu) variant of IRAG1 (Q9Y6F6)
P357L (p.Pro357Leu) in IRAG1 (Q9Y6F6) is a missense change. The available variant effect predictions contribute to a CATVariant prioritization score of 0.15 / 1. The record also includes population frequency data and structural context.
P357L (p.Pro357Leu) variant details
- p.Pro357Leu
- cosmic curated COSV10534
- Missense
- Variant Prioritization Score for Impact Estimate 0.146
- REVEL 0.04
- MetaLR 0.03
- MetaSVM -1.03
- CADD 13.20
- PolyPhen-2 0.00
- SIFT 0.05
- Most common in the Ashkenazi Jewish population (allele frequency 3.9e-05)
- Structural context available