I277T (p.Ile277Thr) variant of IRAG1 (Q9Y6F6)
I277T (p.Ile277Thr) in IRAG1 (Q9Y6F6) is a missense change. Clinical records from ClinVar and UniProt describe it as likely benign in the context of not specified. The available variant effect predictions contribute to a CATVariant prioritization score of 0.23 / 1. The record also includes population frequency data and structural context.
I277T (p.Ile277Thr) variant details
- p.Ile277Thr
- rs980062384
- NCI-TCGA Cosmic COSV7021
- cosmic curated COSV70211
- TOPMed rs980062384
- Likely benign
- not specified
- Missense
- Variant Prioritization Score for Impact Estimate 0.235
- AlphaMissense 0.09
- MetaLR 0.01
- MetaSVM -0.92
- SIFT 0.35
- ClinVar: Likely benign (not specified)
- UniProt: Likely benign
- Population evidence available
- Structural context available