G65S (p.Gly65Ser) variant of IRAG1 (Q9Y6F6)
G65S (p.Gly65Ser) in IRAG1 (Q9Y6F6) is a missense change. Clinical records from ClinVar, EBI, and UniProt describe it as likely benign in the context of not specified. The available variant effect predictions contribute to a CATVariant prioritization score of 0.24 / 1. The record also includes population frequency data and structural context.
G65S (p.Gly65Ser) variant details
- p.Gly65Ser
- rs763827347
- ClinGen CA5884642
- ClinVar RCV004403144
- ExAC rs763827347
- Likely benign
- not specified
- Missense
- Variant Prioritization Score for Impact Estimate 0.244
- AlphaMissense 0.07
- MetaLR 0.05
- MetaSVM -0.97
- SIFT 0.25
- ClinVar: Likely benign (not specified)
- EBI: Likely benign
- UniProt: Likely benign
- Population evidence available
- Structural context available