S77R (p.Ser77Arg) variant of INSR (Insulin receptor)
S77R (p.Ser77Arg) in INSR (Insulin receptor) is a missense change. The available variant effect predictions contribute to a CATVariant prioritization score of 0.45 / 1. The record also includes population frequency data and structural context.
S77R (p.Ser77Arg) variant details
- p.Ser77Arg
- ExAC rs747157246
- gnomAD rs747157246
- Missense
- Variant Prioritization Score for Impact Estimate 0.446
- REVEL 0.42
- MetaLR 0.44
- MetaSVM -0.36
- CADD 22.50
- PolyPhen-2 0.17
- SIFT 0.07
- Most common in the South Asian population (allele frequency 1.2e-05)
- Structural context available