R6W (p.Arg6Trp) variant of INSR (Insulin receptor)
R6W (p.Arg6Trp) in INSR (Insulin receptor) is a missense change. The available variant effect predictions contribute to a CATVariant prioritization score of 0.18 / 1. The record also includes population frequency data and structural context.
R6W (p.Arg6Trp) variant details
- p.Arg6Trp
- gnomAD rs1171697715
- Missense
- Variant Prioritization Score for Impact Estimate 0.179
- REVEL 0.15
- MetaLR 0.24
- MetaSVM -0.84
- CADD 13.80
- PolyPhen-2 0.00
- SIFT 0.07
- Most common in the Non-Finnish European population (allele frequency 1.1e-06)
- Structural context available