P31L (p.Pro31Leu) variant of INSR (Insulin receptor)
P31L (p.Pro31Leu) in INSR (Insulin receptor) is a missense change. Clinical records from UniProt describe it as variant assessed as somatic; moderate impact. The available variant effect predictions contribute to a CATVariant prioritization score of 0.30 / 1. The record also includes population frequency data and structural context.
P31L (p.Pro31Leu) variant details
- p.Pro31Leu
- NCI-TCGA TCGA novel
- Ensembl rs1968562794
- Variant assessed as somatic; moderate impact.
- Missense
- Variant Prioritization Score for Impact Estimate 0.301
- REVEL 0.13
- MetaLR 0.22
- MetaSVM -0.69
- CADD 20.80
- PolyPhen-2 0.00
- SIFT 0.12
- UniProt: Variant assessed as somatic; moderate impact.
- Most common in the REMAINING population (allele frequency 2.1e-05)
- Structural context available