M137V (p.Met137Val) variant of INSR (Insulin receptor)
M137V (p.Met137Val) in INSR (Insulin receptor) is a missense change. The available variant effect predictions contribute to a CATVariant prioritization score of 0.48 / 1. The record also includes population frequency data and structural context.
M137V (p.Met137Val) variant details
- p.Met137Val
- ExAC rs778361303
- gnomAD rs778361303
- Missense
- Variant Prioritization Score for Impact Estimate 0.482
- REVEL 0.51
- MetaLR 0.36
- MetaSVM -0.34
- CADD 21.00
- PolyPhen-2 0.33
- SIFT 0.06
- Most common in the Non-Finnish European population (allele frequency 6.3e-06)
- Structural context available