M137I (p.Met137Ile) variant of INSR (Insulin receptor)
M137I (p.Met137Ile) in INSR (Insulin receptor) is a missense change. Clinical records from UniProt describe it as variant assessed as somatic; moderate impact. The available variant effect predictions contribute to a CATVariant prioritization score of 0.51 / 1. The record also includes population frequency data and structural context.
M137I (p.Met137Ile) variant details
- p.Met137Ile
- NCI-TCGA Cosmic COSV5715
- cosmic curated COSV57157
- Variant assessed as somatic; moderate impact.
- Missense
- Variant Prioritization Score for Impact Estimate 0.508
- REVEL 0.41
- MetaLR 0.35
- MetaSVM -0.41
- CADD 20.60
- PolyPhen-2 0.10
- SIFT 0.00
- UniProt: Variant assessed as somatic; moderate impact.
- Most common in the REMAINING population (allele frequency 1.7e-05)
- Structural context available