L90F (p.Leu90Phe) variant of INSR (Insulin receptor)
L90F (p.Leu90Phe) in INSR (Insulin receptor) is a missense change. The available variant effect predictions contribute to a CATVariant prioritization score of 0.70 / 1. The record also includes population frequency data and structural context.
L90F (p.Leu90Phe) variant details
- p.Leu90Phe
- ExAC rs757683491
- gnomAD rs757683491
- Missense
- Variant Prioritization Score for Impact Estimate 0.699
- REVEL 0.72
- MetaLR 0.53
- MetaSVM 0.10
- CADD 26.00
- PolyPhen-2 0.71
- SIFT 0.02
- Most common in the South Asian population (allele frequency 1.2e-05)
- Structural context available