I158V (p.Ile158Val) variant of INSR (Insulin receptor)
I158V (p.Ile158Val) in INSR (Insulin receptor) is a missense change. The available variant effect predictions contribute to a CATVariant prioritization score of 0.38 / 1. The record also includes population frequency data and structural context.
I158V (p.Ile158Val) variant details
- p.Ile158Val
- ExAC rs765224661
- TOPMed rs765224661
- gnomAD rs765224661
- Missense
- Variant Prioritization Score for Impact Estimate 0.384
- REVEL 0.32
- MetaLR 0.38
- MetaSVM -0.54
- CADD 19.90
- PolyPhen-2 0.25
- SIFT 0.03
- Most common in the African/African-American population (allele frequency 0.00015)
- Structural context available