G4R (p.Gly4Arg) variant of INSR (Insulin receptor)
G4R (p.Gly4Arg) in INSR (Insulin receptor) is a missense change. Clinical records from UniProt describe it as variant assessed as somatic; moderate impact. The available variant effect predictions contribute to a CATVariant prioritization score of 0.21 / 1. The record also includes population frequency data and structural context.
G4R (p.Gly4Arg) variant details
- p.Gly4Arg
- rs1370875449
- gnomAD rs1370875449
- Variant assessed as somatic; moderate impact.
- Missense
- Variant Prioritization Score for Impact Estimate 0.207
- REVEL 0.11
- MetaLR 0.23
- MetaSVM -0.82
- CADD 19.70
- PolyPhen-2 0.00
- SIFT 0.19
- UniProt: Variant assessed as somatic; moderate impact.
- Most common in the REMAINING population (allele frequency 2.3e-05)
- Structural context available