W17C (p.Trp17Cys) variant of INS (Insulin)
W17C (p.Trp17Cys) in INS (Insulin) is a missense change. The available variant effect predictions contribute to a CATVariant prioritization score of 0.48 / 1. The record also includes population frequency data, published literature, and structural context.
W17C (p.Trp17Cys) variant details
- p.Trp17Cys
- gnomAD 11-2160921-C-A
- Missense
- Variant Prioritization Score for Impact Estimate 0.477
- REVEL 0.57
- MetaLR 0.52
- MetaSVM -0.37
- CADD 22.70
- PolyPhen-2 0.34
- SIFT 0.18
- Most common in the Non-Finnish European population (allele frequency 9e-07)
- Structural context available
- Literature evidence available