V63L (p.Val63Leu) variant of INS (Insulin)
V63L (p.Val63Leu) in INS (Insulin) is a missense change. The available variant effect predictions contribute to a CATVariant prioritization score of 0.41 / 1. The record also includes population frequency data and structural context.
V63L (p.Val63Leu) variant details
- p.Val63Leu
- ExAC rs746770373
- gnomAD rs746770373
- Missense
- Variant Prioritization Score for Impact Estimate 0.407
- REVEL 0.23
- MetaLR 0.50
- MetaSVM -0.42
- CADD 26.50
- PolyPhen-2 0.05
- SIFT 0.76
- Most common in the East Asian population (allele frequency 2.5e-05)
- Structural context available