P21S (p.Pro21Ser) variant of INS (Insulin)
P21S (p.Pro21Ser) in INS (Insulin) is a missense change. The available variant effect predictions contribute to a CATVariant prioritization score of 0.34 / 1. The record also includes population frequency data and structural context.
P21S (p.Pro21Ser) variant details
- p.Pro21Ser
- TOPMed rs927782619
- gnomAD rs927782619
- Missense
- Variant Prioritization Score for Impact Estimate 0.336
- REVEL 0.32
- MetaLR 0.74
- MetaSVM -0.21
- CADD 4.89
- PolyPhen-2 0.01
- SIFT 1.00
- Most common in the Non-Finnish European population (allele frequency 1.5e-05)
- Structural context available