D60Y (p.Asp60Tyr) variant of INS (Insulin)
D60Y (p.Asp60Tyr) in INS (Insulin) is a missense change. The available variant effect predictions contribute to a CATVariant prioritization score of 0.51 / 1. The record also includes population frequency data and structural context.
D60Y (p.Asp60Tyr) variant details
- p.Asp60Tyr
- TOPMed rs954838167
- gnomAD rs954838167
- Missense
- Variant Prioritization Score for Impact Estimate 0.509
- REVEL 0.54
- MetaLR 0.83
- MetaSVM 0.20
- CADD 22.40
- PolyPhen-2 0.96
- SIFT 0.03
- Most common in the Non-Finnish European population (allele frequency 6.3e-06)
- Structural context available