G28R (p.Gly28Arg) variant of IL7R (P16871)
G28R (p.Gly28Arg) in IL7R (P16871) is a missense change. Clinical records from UniProt describe it as variant assessed as somatic; moderate impact. The available variant effect predictions contribute to a CATVariant prioritization score of 0.73 / 1. The record also includes population frequency data and structural context.
G28R (p.Gly28Arg) variant details
- p.Gly28Arg
- gnomAD rs1234733163
- NCI-TCGA Cosmic COSV5740
- cosmic curated COSV57409
- Variant assessed as somatic; moderate impact.
- Missense
- Variant Prioritization Score for Impact Estimate 0.727
- REVEL 0.64
- CADD 34.00
- PolyPhen-2 0.98
- SIFT 0.00
- UniProt: Variant assessed as somatic; moderate impact.
- Most common in the REMAINING population (allele frequency 1.7e-05)
- Structural context available