T46I (p.Thr46Ile) variant of IL6R (P08887)
T46I (p.Thr46Ile) in IL6R (P08887) is a missense change. The available variant effect predictions contribute to a CATVariant prioritization score of 0.10 / 1. The record also includes population frequency data, published literature, and structural context.
T46I (p.Thr46Ile) variant details
- p.Thr46Ile
- gnomAD 1-154429247-C-T
- Missense
- Variant Prioritization Score for Impact Estimate 0.101
- REVEL 0.04
- MetaLR 0.01
- MetaSVM -0.96
- CADD 11.00
- PolyPhen-2 0.01
- SIFT 0.15
- Most common in the Non-Finnish European population (allele frequency 3.6e-06)
- Structural context available
- Literature evidence available