R24P (p.Arg24Pro) variant of IL6R (P08887)
R24P (p.Arg24Pro) in IL6R (P08887) is a missense change. The available variant effect predictions contribute to a CATVariant prioritization score of 0.12 / 1. The record also includes population frequency data, published literature, and structural context.
R24P (p.Arg24Pro) variant details
- p.Arg24Pro
- gnomAD 1-154405700-G-C
- Missense
- Variant Prioritization Score for Impact Estimate 0.119
- REVEL 0.09
- MetaLR 0.01
- MetaSVM -0.94
- CADD 8.36
- PolyPhen-2 0.02
- SIFT 0.37
- Most common in the Non-Finnish European population (allele frequency 1.9e-06)
- Structural context available
- Literature evidence available