R24L (p.Arg24Leu) variant of IL6R (P08887)
R24L (p.Arg24Leu) in IL6R (P08887) is a missense change. The available variant effect predictions contribute to a CATVariant prioritization score of 0.08 / 1. The record also includes population frequency data, published literature, and structural context.
R24L (p.Arg24Leu) variant details
- p.Arg24Leu
- gnomAD 1-154405700-G-T
- Missense
- Variant Prioritization Score for Impact Estimate 0.0799
- REVEL 0.01
- MetaLR 0.01
- MetaSVM -0.94
- CADD 7.28
- PolyPhen-2 0.00
- SIFT 0.39
- Most common in the Non-Finnish European population (allele frequency 9.3e-07)
- Structural context available
- Literature evidence available