R23T (p.Arg23Thr) variant of IL6R (P08887)
R23T (p.Arg23Thr) in IL6R (P08887) is a missense change. The available variant effect predictions contribute to a CATVariant prioritization score of 0.08 / 1. The record also includes population frequency data, published literature, and structural context.
R23T (p.Arg23Thr) variant details
- p.Arg23Thr
- gnomAD 1-154405697-G-C
- Missense
- Variant Prioritization Score for Impact Estimate 0.0829
- REVEL 0.02
- MetaLR 0.01
- MetaSVM -0.95
- CADD 7.33
- PolyPhen-2 0.00
- SIFT 0.55
- Most common in the South Asian population (allele frequency 1.3e-05)
- Structural context available
- Literature evidence available