R23S (p.Arg23Ser) variant of IL6R (P08887)
R23S (p.Arg23Ser) in IL6R (P08887) is a missense change. The available variant effect predictions contribute to a CATVariant prioritization score of 0.19 / 1. The record also includes population frequency data, published literature, and structural context.
R23S (p.Arg23Ser) variant details
- p.Arg23Ser
- gnomAD 1-154405698-G-T
- Missense
- Variant Prioritization Score for Impact Estimate 0.189
- REVEL 0.04
- MetaLR 0.01
- MetaSVM -0.96
- CADD 10.80
- PolyPhen-2 0.00
- SIFT 0.70
- Most common in the Non-Finnish European population (allele frequency 9.3e-07)
- Structural context available
- Literature evidence available