R23G (p.Arg23Gly) variant of IL6R (P08887)
R23G (p.Arg23Gly) in IL6R (P08887) is a missense change. The available variant effect predictions contribute to a CATVariant prioritization score of 0.10 / 1. The record also includes population frequency data, published literature, and structural context.
R23G (p.Arg23Gly) variant details
- p.Arg23Gly
- gnomAD 1-154405696-A-G
- Missense
- Variant Prioritization Score for Impact Estimate 0.101
- REVEL 0.03
- MetaLR 0.01
- MetaSVM -0.96
- CADD 10.70
- PolyPhen-2 0.00
- SIFT 1.00
- Most common in the South Asian population (allele frequency 2.6e-05)
- Structural context available
- Literature evidence available