P22S (p.Pro22Ser) variant of IL6R (P08887)
P22S (p.Pro22Ser) in IL6R (P08887) is a missense change. The available variant effect predictions contribute to a CATVariant prioritization score of 0.12 / 1. The record also includes population frequency data, published literature, and structural context.
P22S (p.Pro22Ser) variant details
- p.Pro22Ser
- gnomAD 1-154405693-C-T
- Missense
- Variant Prioritization Score for Impact Estimate 0.118
- REVEL 0.04
- MetaLR 0.01
- MetaSVM -0.99
- CADD 7.04
- PolyPhen-2 0.00
- SIFT 0.46
- Population evidence available
- Structural context available
- Literature evidence available