P22R (p.Pro22Arg) variant of IL6R (P08887)
P22R (p.Pro22Arg) in IL6R (P08887) is a missense change. The available variant effect predictions contribute to a CATVariant prioritization score of 0.12 / 1. The record also includes population frequency data, published literature, and structural context.
P22R (p.Pro22Arg) variant details
- p.Pro22Arg
- gnomAD 1-154405694-C-G
- Missense
- Variant Prioritization Score for Impact Estimate 0.117
- REVEL 0.06
- MetaLR 0.01
- MetaSVM -1.01
- CADD 6.30
- PolyPhen-2 0.14
- SIFT 0.16
- Population evidence available
- Structural context available
- Literature evidence available