P16S (p.Pro16Ser) variant of IL6R (P08887)
P16S (p.Pro16Ser) in IL6R (P08887) is a missense change. The available variant effect predictions contribute to a CATVariant prioritization score of 0.16 / 1. The record also includes population frequency data, published literature, and structural context.
P16S (p.Pro16Ser) variant details
- p.Pro16Ser
- gnomAD 1-154405675-C-T
- Missense
- Variant Prioritization Score for Impact Estimate 0.159
- REVEL 0.03
- MetaLR 0.01
- MetaSVM -0.96
- CADD 5.63
- PolyPhen-2 0.00
- SIFT 0.39
- Most common in the REMAINING population (allele frequency 1.7e-05)
- Structural context available
- Literature evidence available