L8P (p.Leu8Pro) variant of IL6R (P08887)
L8P (p.Leu8Pro) in IL6R (P08887) is a missense change. The available variant effect predictions contribute to a CATVariant prioritization score of 0.32 / 1. The record also includes population frequency data, published literature, and structural context.
L8P (p.Leu8Pro) variant details
- p.Leu8Pro
- gnomAD 1-154405652-T-C
- Missense
- Variant Prioritization Score for Impact Estimate 0.323
- REVEL 0.24
- MetaLR 0.06
- MetaSVM -1.11
- CADD 22.80
- PolyPhen-2 0.96
- SIFT 0.01
- Population evidence available
- Structural context available
- Literature evidence available