L20M (p.Leu20Met) variant of IL6R (P08887)
L20M (p.Leu20Met) in IL6R (P08887) is a missense change. The available variant effect predictions contribute to a CATVariant prioritization score of 0.22 / 1. The record also includes population frequency data, published literature, and structural context.
L20M (p.Leu20Met) variant details
- p.Leu20Met
- gnomAD 1-154405687-C-A
- Missense
- Variant Prioritization Score for Impact Estimate 0.217
- REVEL 0.08
- MetaLR 0.04
- MetaSVM -1.07
- CADD 14.70
- PolyPhen-2 0.46
- SIFT 0.25
- Population evidence available
- Structural context available
- Literature evidence available