L12M (p.Leu12Met) variant of IL6R (P08887)
L12M (p.Leu12Met) in IL6R (P08887) is a missense change. The available variant effect predictions contribute to a CATVariant prioritization score of 0.21 / 1. The record also includes population frequency data, published literature, and structural context.
L12M (p.Leu12Met) variant details
- p.Leu12Met
- gnomAD 1-154405663-C-A
- Missense
- Variant Prioritization Score for Impact Estimate 0.214
- REVEL 0.10
- MetaLR 0.05
- MetaSVM -1.11
- CADD 20.90
- PolyPhen-2 0.94
- SIFT 0.05
- Population evidence available
- Structural context available
- Literature evidence available