C25F (p.Cys25Phe) variant of IL6R (P08887)
C25F (p.Cys25Phe) in IL6R (P08887) is a missense change. The available variant effect predictions contribute to a CATVariant prioritization score of 0.32 / 1. The record also includes population frequency data, published literature, and structural context.
C25F (p.Cys25Phe) variant details
- p.Cys25Phe
- gnomAD 1-154405703-G-T
- Missense
- Variant Prioritization Score for Impact Estimate 0.321
- REVEL 0.08
- MetaLR 0.06
- MetaSVM -1.11
- CADD 24.10
- PolyPhen-2 0.73
- SIFT 0.03
- Population evidence available
- Structural context available
- Literature evidence available