Y59H (p.Tyr59His) variant of IL6 (Interleukin-6)
Y59H (p.Tyr59His) in IL6 (Interleukin-6) is a missense change. Clinical records from ClinVar and UniProt describe it as uncertain significance in the context of not specified. The available variant effect predictions contribute to a CATVariant prioritization score of 0.09 / 1. The record also includes population frequency data and structural context.
Y59H (p.Tyr59His) variant details
- p.Tyr59His
- rs201822486
- NCI-TCGA Cosmic COSV9933
- cosmic curated COSV99331
- TOPMed rs201822486
- Uncertain significance
- not specified
- Missense
- Variant Prioritization Score for Impact Estimate 0.0862
- REVEL 0.04
- MetaLR 0.03
- MetaSVM -1.00
- CADD 4.96
- PolyPhen-2 0.03
- SIFT 0.24
- ClinVar: Uncertain significance (not specified)
- UniProt: Uncertain significance
- Most common in the Latino/Admixed American population (allele frequency 0.00013)
- Structural context available