V12L (p.Val12Leu) variant of IL6 (Interleukin-6)
V12L (p.Val12Leu) in IL6 (Interleukin-6) is a missense change. The available variant effect predictions contribute to a CATVariant prioritization score of 0.21 / 1. The record also includes population frequency data and structural context.
V12L (p.Val12Leu) variant details
- p.Val12Leu
- gnomAD rs1784030327
- Missense
- Variant Prioritization Score for Impact Estimate 0.208
- REVEL 0.23
- MetaLR 0.28
- MetaSVM -0.92
- CADD 8.25
- PolyPhen-2 0.01
- SIFT 0.57
- Most common in the South Asian population (allele frequency 0.00021)
- Structural context available