T6K (p.Thr6Lys) variant of IL6 (Interleukin-6)
T6K (p.Thr6Lys) in IL6 (Interleukin-6) is a missense change. The available variant effect predictions contribute to a CATVariant prioritization score of 0.40 / 1. The record also includes population frequency data, published literature, and structural context.
T6K (p.Thr6Lys) variant details
- p.Thr6Lys
- gnomAD 7-22727279-C-A
- Missense
- Variant Prioritization Score for Impact Estimate 0.397
- REVEL 0.23
- MetaLR 0.59
- MetaSVM -0.41
- CADD 31.00
- PolyPhen-2 0.81
- SIFT 0.04
- Most common in the African/African-American population (allele frequency 3e-05)
- Structural context available
- Literature evidence available