T6I (p.Thr6Ile) variant of IL6 (Interleukin-6)
T6I (p.Thr6Ile) in IL6 (Interleukin-6) is a missense change. The available variant effect predictions contribute to a CATVariant prioritization score of 0.38 / 1. The record also includes population frequency data and structural context.
T6I (p.Thr6Ile) variant details
- p.Thr6Ile
- ExAC rs774003579
- TOPMed rs774003579
- gnomAD rs774003579
- Missense
- Variant Prioritization Score for Impact Estimate 0.379
- REVEL 0.19
- MetaLR 0.55
- MetaSVM -0.46
- CADD 33.00
- PolyPhen-2 0.92
- SIFT 0.07
- Most common in the REMAINING population (allele frequency 1.7e-05)
- Structural context available