S5F (p.Ser5Phe) variant of IL6 (Interleukin-6)
S5F (p.Ser5Phe) in IL6 (Interleukin-6) is a missense change. The available variant effect predictions contribute to a CATVariant prioritization score of 0.18 / 1. The record also includes population frequency data and structural context.
S5F (p.Ser5Phe) variant details
- p.Ser5Phe
- TOPMed rs1224052258
- gnomAD rs1224052258
- Missense
- Variant Prioritization Score for Impact Estimate 0.181
- REVEL 0.14
- MetaLR 0.22
- MetaSVM -0.91
- CADD 16.90
- PolyPhen-2 0.06
- SIFT 0.35
- Most common in the Latino/Admixed American population (allele frequency 0.00059)
- Structural context available