S49F (p.Ser49Phe) variant of IL6 (Interleukin-6)
S49F (p.Ser49Phe) in IL6 (Interleukin-6) is a missense change. The available variant effect predictions contribute to a CATVariant prioritization score of 0.26 / 1. The record also includes population frequency data, published literature, and structural context.
S49F (p.Ser49Phe) variant details
- p.Ser49Phe
- gnomAD 7-22727570-C-T
- Missense
- Variant Prioritization Score for Impact Estimate 0.255
- REVEL 0.16
- CADD 22.80
- PolyPhen-2 0.91
- SIFT 0.04
- Most common in the Non-Finnish European population (allele frequency 3.6e-06)
- Structural context available
- Literature evidence available